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1

Enzyme-activated irreversible inhibitors of monoamine oxidase: phenylallylamine structure-activity relationships

McDonald, Ian A., Lacoste, Jean Michel, Bey, Philippe, Palfreyman, Michael G., Zreika, Monique

Journal:

Journal of Medicinal Chemistry

Année:

1985

Langue:

english

Fichier:

PDF, 1.77 MB

english, 1985

2

ChemInform Abstract: The Synthesis of Ketomethylene Pseudopeptide Analogues of Dipeptide Aldehyde Inhibitors of Calpain.

Michael R. Angelastro, Angela L. Marquart, Shujaath Mehdi, Jack R. Koehl, Roy J. Vaz, Philippe Bey, Norton P. Peet

Journal:

Année:

1999

Fichier:

PDF, 33 KB

1999

3

ChemInform Abstract: Novel Steroidal Vinyl Fluorides as Inhibitors of Steroid C17(20) Lyase.

Joseph P. Burkhart, Philip M. Weintraub, Cynthia A. Gates, Robert J. Resvick, Roy J. Vaz, Dirk Friederich, Michael R. Angelastro, Philippe Bey, Norton P. Peet

Journal:

Année:

2002

Fichier:

PDF, 27 KB

2002

4

Dual enzyme-activated irreversible inhibition of monoamine oxidase

Ian A. McDonald, Jean Michel Lacoste, Philippe Bey, Joseph Wagner, Monique Zreika, Michael G. Palfreyman

Journal:

Bioorganic Chemistry

Année:

1986

Langue:

english

Fichier:

PDF, 1.03 MB

english, 1986

5

Cognitive OFDM system detection using pilot tones second and third-order cyclostationarity

François-Xavier Socheleau, Sébastien Houcke, Philippe Ciblat, Abdeldjalil Aïssa-El-Bey

Journal:

Signal Processing

Année:

2011

Langue:

english

Fichier:

PDF, 885 KB

english, 2011

6

A novel method for the preparation of peptidyl α-keto esters

Joseph P. Burkhart, Norton P. Peet, Philippe Bey

Journal:

Tetrahedron Letters

Année:

1990

Langue:

english

Fichier:

PDF, 235 KB

english, 1990

7

A general preparation of fluoroallylamine enzyme inhibitors incorporating a β-substituted heteroatom

Ian A. McDonald, Philippe Bey

Journal:

Tetrahedron Letters

Année:

1985

Langue:

english

Fichier:

PDF, 167 KB

english, 1985

8

Synthesis of (E)-β-fluoromethyleneglutamic acid

Ian A. McDonald, Michael G. Palfreyman, Michel Jung, Philippe Bey

Journal:

Tetrahedron Letters

Année:

1985

Langue:

english

Fichier:

PDF, 123 KB

english, 1985

9

Efficient preparation of peptidyl pentaflouroethly ketones

Michael R. Angeloastro, Joseph P. Burkhart, Philippe Bey, Norton P. Peet

Journal:

Tetrahedron Letters

Année:

1992

Langue:

english

Fichier:

PDF, 211 KB

english, 1992

10

The conversion of a diazolactam to an α-methylenelactam: An entrance to new conformationally restricted inhibitors of angiotensin-converting enzyme

Gary A Flynn, Douglas W Beight, Edward W Huber, Philippe Bey

Journal:

Tetrahedron Letters

Année:

1990

Langue:

english

Fichier:

PDF, 197 KB

english, 1990

11

A convenient synthetic access to β, β-difluoro-γ-keto-α-amino acids. Application to the synthesis of a potential inhibitor of kynureninase

Jeffrey P. Whitten, Charlotte L. Barney, Edward W. Huber, Philippe Bey, James R. McCarthy

Journal:

Tetrahedron Letters

Année:

1989

Langue:

english

Fichier:

PDF, 236 KB

english, 1989

12

Preparation de glycols 2β, 3β a partir d'α - dicetones polycycliques

Philippe Bey, Robert Hanna

Journal:

Tetrahedron Letters

Année:

1970

Fichier:

PDF, 238 KB

1970

13

Factors affecting local control and survival after treatment of carcinoma of the rectum by endocavitary radiation: A retrospective study of 97 cases

Philippe Rauch, Pierre Bey, Didier Peiffert, Thierry Conroy, Laurent Bresler

Journal:

International Journal of Radiation Oncology*Biology*Physics

Année:

2001

Langue:

english

Fichier:

PDF, 185 KB

english, 2001

14

Results of a european randomized trial of Etanidazole combined with radiotherapy in head and neck carcinomas

François Eschwège, Hélène Sancho-Garnier, Daniel Chassagne, Denis Brisgand, Marta Guerra, Edmond Philippe Malaise, Pierre Bey, Luciano Busutti, Luca Cionini, Tan N'Guyen, Alberto Romanini, Jean Chavau

Journal:

International Journal of Radiation Oncology*Biology*Physics

Année:

1997

Langue:

english

Fichier:

PDF, 653 KB

english, 1997

15

Synthesis of a peptidyl 2,2-difluoro-3-aminopropionate

Michael R. Angelastro, Philippe Bey, Shujaath Mehdi, Norton P. Peet

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1992

Langue:

english

Fichier:

PDF, 225 KB

english, 1992

16

An acyliminium ion route to Cis and Trans “Anti” phe-gly dipeptide mimetics

Gary A. Flynn, Timothy P. Burkholder, Edward W. Huber, Philippe Bey

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1991

Langue:

english

Fichier:

PDF, 325 KB

english, 1991

17

Janus compounds: dual inhibitors of proteinases

Michael R. Angelastro, Philippe Bey, Shujaath Mehdi, Michael J. Janusz, Norton P. Peet

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1993

Langue:

english

Fichier:

PDF, 380 KB

english, 1993

18

Preparation of α-keto ester enol acetates as potential prodrugs of human neutrophil elastase inhibitors

Joseph P. Burkhart, Shujaath Mehdi, Jack R. Koehl, Michael R. Angelastro, Philippe Bey, Norton P. Peet

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1998

Langue:

english

Fichier:

PDF, 127 KB

english, 1998

19

The synthesis of ketomethylene pseudopeptide analogues of dipeptide aldehyde inhibitors of calpain

Michael R. Angelastro, Angela L. Marquart, Shujaath Mehdi, Jack R. Koehl, Roy J. Vaz, Philippe Bey, Norton P. Peet

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1999

Langue:

english

Fichier:

PDF, 122 KB

english, 1999

20

Novel Steroidal Vinyl Fluorides as Inhibitors of Steroid C17(20) Lyase

Joseph P Burkhart, Philip M Weintraub, Cynthia A Gates, Robert J Resvick, Roy J Vaz, Dirk Friedrich, Michael R Angelastro, Philippe Bey, Norton P Peet

Journal:

Bioorganic & Medicinal Chemistry

Année:

2002

Langue:

english

Fichier:

PDF, 157 KB

english, 2002

21

Oxidation of α-hydroxy esters to α-keto esters using the dess-martin periodinane reagent

Joseph P Burkhart, Norton P Peet, Philippe Bey

Journal:

Tetrahedron Letters

Année:

1988

Langue:

english

Fichier:

PDF, 307 KB

english, 1988

22

Synthesis of 21,21-Difluoro-3β-hydroxy-20-methylpregna-5,20-diene and 5,16,20-Triene as potential inhibitors of steroid C17(20) lyase

Philip M Weintraub, Amy K Holland, Cynthia A Gates, William R Moore, Robert J Resvick, Philippe Bey, Norton P Peet

Journal:

Bioorganic & Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 152 KB

english, 2003

23

THE IRREVERSIBLE INHIBITION OF BRAIN L-GLUTAMATE-I-DECARBOXYLASE BY (2RS,3E)-2-METHYL-3,4-DIDEHYDROGLUTAMIC ACID

Ewan Chrystal, Philippe Bey, Robert R. Rando

Journal:

Journal of Neurochemistry

Année:

1979

Langue:

english

Fichier:

PDF, 525 KB

english, 1979

24

MDL 72145, an Enzyme-Activated Irreversible Inhibitor with Selectivity for Monoamine Oxidase Type B

Monique Zreika, Ian A. McDonald, Philippe Bey, Michael G. Palfreyman

Journal:

Journal of Neurochemistry

Année:

1984

Langue:

english

Fichier:

PDF, 563 KB

english, 1984

25

Inhibition of Monoamine Oxidase Selectively in Brain Monoamine Nerves Using the Bioprecursor (E-β-Fluoromethylene-m-Tyrosine (MDL 72394), a Substrate for Aromatic L-Amino Acid Decarboxylase

Michael G. Palfreyman, Ian A. McDonald, John R. Fozard, Yves Mely, Andrew J. Sleight, Monique Zreika, Joseph Wagner, Philippe Bey, Peter J. Lewis

Journal:

Journal of Neurochemistry

Année:

1985

Langue:

english

Fichier:

PDF, 1.16 MB

english, 1985

26

The synthesis of acyclonucleoside hydroxamic acids as inhibitors of ribonucleotide reductase

Farr, Robert A., Bey, Philippe, Sunkara, Prasad S., Lippert, Bruce J.

Journal:

Journal of Medicinal Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 936 KB

english, 1989

27

The specificity of two proteinases that cleave adjacent to arginine, Cl esterase and acrosin, for peptide p-nitroanilide substrates

Mark T. Skoog, Shujaath Mehdi, Jeffrey S. Wiseman, Philippe Bey

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Année:

1989

Langue:

english

Fichier:

PDF, 840 KB

english, 1989

28

Pharmacogenomics: challenges and opportunities

Norton P. Peet, Philippe Bey

Journal:

Drug Discovery Today

Année:

2001

Langue:

english

Fichier:

PDF, 50 KB

english, 2001

29

17β-(Cyclopropylamino)-androst-5-en-3β-ol, a selective mechanism-based inhibitor of cytochrome P45017α (steroid 17α-hydroxylase/C17–20 lyase)

Michael R. Angelastro, Marie E. Laughlin, Gerald L. Schatzman, Philippe Bey, Thomas R. Blohm

Journal:

Biochemical and Biophysical Research Communications

Année:

1989

Langue:

english

Fichier:

PDF, 425 KB

english, 1989

30

The inhibition of human neutrophil elastase and cathepsin G by peptidyl 1,2-dicarbonyl derivatives

Shujaath Mehdi, Michael P. Angelastro, Joseph P. Burkhart, Jack R. Koehl, Norton P. Peet, Philippe Bey

Journal:

Biochemical and Biophysical Research Communications

Année:

1990

Langue:

english

Fichier:

PDF, 433 KB

english, 1990

31

α-monofluoromethyl and α-difluoromethyl putrescine as ornithine decarboxylase inhibitors: In vitro and in vivo biochemical properties

Charles Danzin, Philippe bey, Daniel Schirlin, Nicole Claverie

Journal:

Biochemical Pharmacology

Année:

1982

Langue:

english

Fichier:

PDF, 989 KB

english, 1982

32

Marked and prolonged inhibition of mammalian ornithine decarboxylase in vivo by esters of (E)-2-(fluoromethyl)dehydroornithine

Pierre S. Mamont, Charles Danzin, Michael Kolb, Fritz Gerhart, Philippe Bey, Albert Sjoerdsma

Journal:

Biochemical Pharmacology

Année:

1986

Langue:

english

Fichier:

PDF, 719 KB

english, 1986

33

(Z)-2-(2,4-Dichlorophenoxy)methyl-3-fluoroallylamine (MDL 72638): a clorgyline analogue with surprising selectivity for monoamine oxidase type B

Ian A. McDonald, Michael G. Palfreyman, Monique Zreika, Philippe Bey

Journal:

Biochemical Pharmacology

Année:

1986

Langue:

english

Fichier:

PDF, 425 KB

english, 1986

34

Inhibition of rat aorta semicarbazide-sensitive amine oxidase by 2-phenyl-3-haloallylamines and related compounds

Geoffrey A. Lyles, C.M. Susan Marshall, Ian A. McDonald, Philippe Bey, Michael G. Palfreyman

Journal:

Biochemical Pharmacology

Année:

1987

Langue:

english

Fichier:

PDF, 615 KB

english, 1987

35

Is the deltopectoral flap born again? Role in postburn head and neck reconstruction

Eric Bey, Aurélie Hautier, Jean-Philippe Pradier, Patrick Duhamel

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 1.68 MB

english, 2009

36

Inhibition of growth of Mycoplasma dispar by DL-α-Difluoromethyllysine, a selective irreversible inhibitor of lysine decarboxylase, and reversal by cadaverine (1,5-diaminopentane)

Hannu Pösö, Peter P. McCann, Raili Tanskanen, Philippe Bey, Albert Sjoerdsma

Journal:

Biochemical and Biophysical Research Communications

Année:

1984

Langue:

english

Fichier:

PDF, 255 KB

english, 1984

37

Inhibition of the proteolysis of rat erythrocyte membrane proteins by a synthetic inhibitor of calpain

Shujaath Mehdi, Michael R. Angelastro, Jeffery S. Wiseman, Philippe Bey

Journal:

Biochemical and Biophysical Research Communications

Année:

1988

Langue:

english

Fichier:

PDF, 1.62 MB

english, 1988

38

FURTHER STUDIES ON THE INHIBITION OF MONOAMINE SYNTHESIS BY MONOFLUOROMETHYLDOPA

PHILIPPE BEY, MICHEL J. JUNG, JAN KOCH-WESER, MICHAEL G. PALFREYMAN, ALBERT SJOERDSMA, JOSEPH WAGNER, MONIQUE ZRAÏKA

Journal:

British Journal of Pharmacology

Année:

1980

Langue:

english

Fichier:

PDF, 662 KB

english, 1980

39

Design and early clinical evaluation of selective inhibitors of monoamine oxidase

Michael G. Palfreyman, Ian A. McDonald, Philippe Bey, Paul J. Schechter, Albert Sjoerdsma

Journal:

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Année:

1988

Langue:

english

Fichier:

PDF, 1.05 MB

english, 1988

40

Anti-proliferative properties of DL-α-difluoromethyl ornithine in cultured cells. A consequence of the irreversible inhibition of ornithine decarboxylase

Pierre S. Mamont, Marie-Christine Duchesne, Jeffrey Grove, Philippe Bey

Journal:

Biochemical and Biophysical Research Communications

Année:

1978

Langue:

english

Fichier:

PDF, 437 KB

english, 1978

41

General synthetic access to α-allenyl amines and α-allenyl-α-aminoacids as potential enzyme activated irreversible inhibitors of PLP dependent enzymes

Patrick Casara, Karin Jund, Philippe Bey

Journal:

Tetrahedron Letters

Année:

1984

Langue:

english

Fichier:

PDF, 220 KB

english, 1984

42

Effect of α-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on polyamine levels in rat tissues

Charles Danzin, Michel J. Jung, Jeffrey Grove, Philippe Bey

Journal:

Année:

1979

Langue:

english

Fichier:

PDF, 255 KB

english, 1979

43

Stereospecific method to (E) and (Z) terminal fluoroolefins and its application to the synthesis of 2'-deoxy-2'-fluoromethylenenucleosides as potential inhibitors of ribonucleoside diphosphate reductase

McCarthy, James R., Matthews, Donald P., Stemerick, David M., Huber, Edward W., Bey, Philippe, Lippert, Bruce J., Snyder, Ronald D., Sunkara, Prasad S.

Journal:

Journal of the American Chemical Society

Année:

1991

Langue:

english

Fichier:

PDF, 290 KB

english, 1991

44

DL-.alpha.-(Difluoromethyl)arginine: a potent enzyme-activated irreversible inhibitor of bacterial arginine decarboxylases

Kallio, Arja, McCann, Peter P., Bey, Philippe

Journal:

Année:

1981

Langue:

english

Fichier:

PDF, 538 KB

english, 1981

45

Electrical characterization of CNT contacts with Cu Damascene top contact

van der Veen, Marleen H., Vereecke, Bart, Huyghebaert, Cedric, Cott, Daire J., Sugiura, Masahito, Kashiwagi, Yusaku, Teugels, Lieve, Caluwaerts, Rudy, Chiodarelli, Nicolò, Vereecken, Philippe M., Beye

Journal:

Microelectronic Engineering

Année:

2013

Langue:

english

Fichier:

PDF, 824 KB

english, 2013

46

.alpha.-Diketone and .alpha.-keto ester derivatives of N-protected amino acids and peptides as novel inhibitors of cysteine and serine proteinases

Angelastro, Michael R., Mehdi, Shujaath, Burkhart, Joseph P., Peet, Norton P., Bey, Philippe

Journal:

Journal of Medicinal Chemistry

Année:

1990

Langue:

english

Fichier:

PDF, 421 KB

english, 1990

47

Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis

Sugimoto, Hikaru, LeBleu, Valerie S, Bosukonda, Dattatreyamurty, Keck, Peter, Taduri, Gangadhar, Bechtel, Wibke, Okada, Hirokazu, Carlson, William, Bey, Philippe, Rusckowski, Mary, Tampe, Björn, Tampe

Journal:

Nature Medicine

Année:

2012

Langue:

english

Fichier:

PDF, 1.94 MB

english, 2012

48

Reply to Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3

Sugimoto, Hikaru, LeBleu, Valerie S, Bosukonda, Dattatreyamurty, Keck, Peter, Taduri, Gangadhar, Bechtel, Wibke, Okada, Hirokazu, Carlson, William, Bey, Philippe, Rusckowski, Mary, Tampe, Björn, Tampe

Journal:

Nature Medicine

Année:

2013

Langue:

english

Fichier:

PDF, 164 KB

english, 2013

49

A novel synthesis of xanthines: support for a new binding mode for xanthines with respect to adenosine at adenosine receptors

Peet, Norton P., Lentz, Nelsen L., Meng, Elaine C., Dudley, Mark W., Ogden, Ann Marie L., Demeter, David A., Weintraub, Herschel J. R., Bey, Philippe

Journal:

Journal of Medicinal Chemistry

Année:

1990

Langue:

english

Fichier:

PDF, 2.33 MB

english, 1990

50

Direct synthesis of .alpha.-halogenomethyl-.alpha.-amino acids from the parent .alpha.-amino acids

Bey, Philippe, Vevert, Jean Paul, Van Dorsselaer, Viviane, Kolb, Michael

Journal:

Journal of Organic Chemistry

Année:

1979

Langue:

english

Fichier:

PDF, 1.64 MB

english, 1979